Characterization of T cells cultured from fine needle aspirates of human renal allografts during rejection

Computerized Diagnosis of Breast Fine-Needle Aspirates

The goal of this work is to determine the accuracy of computer-based image analysis in diagnosing breast fine-needle aspirates (FNA). On 192 FNAs, the computerbased diagnostic accuracy was 97.9%. This is consistent with the 97.5% accuracy projected by machine learning methods during the initial training in 1994 with 569 FNAs. One of the attributes of this system is the rendering of a value that...

Ultrastructural analysis of fine needle aspirates from benign breast lesions.

Thirty six fine needle aspirates from various types of benign breast lesions were examined by electron microscopy and correlated with their cytological appearances. In all cases the parenchyma consisted of clumps of cohesive cells with the ultrastructural features of epithelial cells. In many cases, particularly from fibroadenomas, the parenchyma consisted of single layers of polarised epitheli...

Needle Aspirates of Melanoma Metastases Expansion of Tumor-T Cell Pairs from Fine Marincola

Propagation of genetically altered tumor cells derived from fine-needle aspirates of primary breast carcinoma.

Because primary breast tumors are diagnosed earlier in the clinic, procurement of sufficient amounts of tumor tissue for in-depth biological characterization is becoming increasingly difficult. We demonstrate here that relatively small numbers of tumor cells within samples of fine-needle aspirates (FNA) can be propagated in culture. Of 25 cases attempted, 12 were passageable, resulting in up to...

Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas.

Formalin-fixed paraffin-embedded tissue specimens obtained by fine needle aspiration of pancreatic masses from 47 patients were examined retrospectively for cytology and the presence of mutant c-K-ras oncogenes. Point mutations of c-K-ras in codon 12 were detected by RNA-DNA RNAse A mismatch cleavage after in vitro DNA amplification of the cellular c-K-ras sequences by the polymerase chain reac...